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Identifier |
000456741 |
Title |
Συστήματα υποστήριξης αποφάσεων στη χρήση φαρμακευτικών φυτών και φυτικών παραγώγων της παραδοσιακής ιατρικής : ασφάλεια, αλληλεπιδράσεις, ανεπιθύμητες ενέργειες |
Alternative Title |
Decision support system for the use of medicinal plants and plant extracts of traditional medicine: safety, interactions, undesirable effects |
Author
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Λαϊνά, Δανάη Γ.
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Thesis advisor
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Πυρίντσος, Στέργιος
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Reviewer
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Κοτζαμπάσης, Κυριάκος
Καλαντίδης, Κρίτων
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Abstract |
Background: The use of herbal medicines for therapeutic purposes is welldocumented throughout human history. The recent resurgence of interest
of plant remedies, either as herbal preparations either as dietary
supplements, in combination with the lack of accurate legal frameworks by
the regulatory authorities has raised concerns about their safety.
Aims of the study: This study aims to contribute in the development of a
decision support system for the selection and consequently for the use of
medicinal plants and their extracts which are used in traditional medicine,
with respect to their safety, the drug – herb interactions and the reported
undesirable effects. Specifically, we suggest a consistent
methodology/process for the generation of a valid safety fingerprinting for
each use of a medicinal plant or plant preparation, which in turn could
lead to the creation of a safety barcode.
Methodology: The methodology includes a data mining approach, using a
series of datasets extracted from various information systems, and data
migration in a system of partial order and recursive partitioning, which has
led to the construction of decision trees, the generation of safety
fingerprinting and safety barcoding.
Results: The overlaps among the information systems used in this study
concerning medicinal plants, were not particular high. Although, the
majority of medicinal plants is considered to be safe and without recorded
drug – herb interactions, the undesirable effects is also an important part
which completes their safety profile. The decision trees’ structure includes
all the paths needed for the decision making process in the selection and
the use of the appropriate medicinal plant whereas partial order system
could be a complementary tool for the selection. Therefore, each plant is
characterized by a unique safety code in the sense of barcode.
Conclusions: The safety of medicinal plants is a complicated issue, which
may include a series of different factors. The system suggested in this
study, considers the available information in a user friendly mode. An
important external limitation of the study is the lack of frequencies
concerning the undesirable effects, implying also the respective lack in the
current pharmacovigilance systems. Nevertheless, the suggested system is
in accordance with the new policies of important organizations such as
FDA and WHO and in case of implementation it could cover fundamental
needs of the health practitioners.
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Language |
Greek |
Issue date |
2017-03-17 |
Collection
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School/Department--School of Sciences and Engineering--Department of Biology--Post-graduate theses
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Type of Work--Post-graduate theses
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Permanent Link |
https://elocus.lib.uoc.gr//dlib/0/3/b/metadata-dlib-1687948150-592283-673.tkl
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Views |
712 |