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Identifier 000382269
Title Study of microRNA-mRNA interactions related with cancer
Alternative Title Μελέτη microRNA-mRNA αλληλεπιδράσεων σχετιζομένων με καρκίνο
Author Καραθανάσης, Νέστορας
Thesis advisor Ποϊράζη, Παναγιώτα
Καλαντίδης, Κρίτων
Abstract MicroRNAs belong to the large family of small non coding RNAs. They regulate protein synthesis by binding to their mRNA targets causing mRNA degradation or translational repression. A large number of miRNAs have been associated with cancer because they are often found to be located within cancer associated genomic region (CAGRs/FRA) to target cancer-related genes, and to be differentially expressed in tumor compared to normal tissues. Previous work in the Computational Biology lab had identified four new putative miRNA genes that were located within CAGR. However their mature molecules and their association with cancer phenotypes were unknown. My thesis focuses on resolving these two issues, using a combination of theoretical and experimental techniques. The specific aims of this work are: -The development of a mature miRNA prediction algorithm(Chapter II, III) -The identification of the mature miRNA molecules of the newly identified miRNA genes via a combination of computational and experimental methods (Chapter IV) -The utilization of a target prediction algorithm to predict and experimentally verify interactions between the mature molecules and cancer-related genes Chapter IV).
Language English
Subject Machine learning
miRNA duplex
Αγγελιοφόρο RNA
Μηχανική μάθηση
Issue date 2014-01-29
Collection   Faculty/Department--Faculty of Sciences and Engineering--Department of Biology--Doctoral theses
  Type of Work--Doctoral theses
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