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Title

Συστήματα μεταφοράς φαρμάκων με βάση τις ανόργανες μήτρες

Alternative Title

Drug delivery systems based on inorganic matrices

Author

Σαρουκιάδης, Μιχάλης

Thesis advisor

Γανωτάκης, Δημήτριος

Abstract

In recent years, bio-inorganic nanomaterials have been increasingly used to deliver drugs to target organs and tissues, due to the development of new analytical techniques and their growing understanding. However, we have yet to find a drug delivery system that can carry biomolecules such as DNA or peptides, while also being selective, economical and stable. This work presents the synthesis of Layered Double Hydroxides, and their derivatives, which are the potential basis for a new class of drug delivery systems. In comparison to most conventional drug delivery systems, LDHs feature the advantages of less complex synthetic routes, as well as a variety of possible structural modifications that can alter or enhance their activity. The main synthetic routes used for the synthesis of LDHs were that of co-precipitation and anion exchange. Co-precipitation typically yields a product of better quality, while anion exchange is more suitable for small scale experiments. The characterization of these nanohybrids was carried out using Xray diffractometers (XRD) and Infrared absorption spectrometry. In addition, this work presents a new technique for the synthesis of biocompatible delaminated LDH (dLDH), based on the use of propylene glycol. Through this method it was possible to trap glutamine and DNA on the surface of dLDH. Additionally, we describe the synthesis and characterization of a LDH-alginate nanohydrid matrix, which is expected to have enhanced stability as compared to crystalline or dLDH. In order to optimize the synthetic process of the matrix we conducted morphological studies using optical microscopy. In addition, drug release assays were conducted simulated plasma serum. The process which was also performed for the LDHNitrofurantoin nanohybrid. It is expected that these new approaches can be used as a basis for the synthesis of more stable, safer and more selective drug carriers, while greatly reducing the cost of synthesis and increasing shelf life.

Language

Greek

Subject

Aminoacids

DNA

Drug Delivery

Gene therapy

Glutamine

Layered double hydroxides (LDH)

Nanohybrids

Nitrofurantoin

Sodium Alginate