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Title |
Συστήματα μεταφοράς φαρμάκων με βάση τις ανόργανες μήτρες |
Alternative Title |
Drug delivery systems based on inorganic matrices |
Author
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Σαρουκιάδης, Μιχάλης
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Thesis advisor
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Γανωτάκης, Δημήτριος
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Abstract |
In recent years, bio-inorganic nanomaterials have been increasingly used to
deliver drugs to target organs and tissues, due to the development of new analytical
techniques and their growing understanding. However, we have yet to find a drug delivery
system that can carry biomolecules such as DNA or peptides, while also being selective,
economical and stable. This work presents the synthesis of Layered Double Hydroxides,
and their derivatives, which are the potential basis for a new class of drug delivery
systems. In comparison to most conventional drug delivery systems, LDHs feature the
advantages of less complex synthetic routes, as well as a variety of possible structural
modifications that can alter or enhance their activity. The main synthetic routes used for
the synthesis of LDHs were that of co-precipitation and anion exchange. Co-precipitation
typically yields a product of better quality, while anion exchange is more suitable for small
scale experiments. The characterization of these nanohybrids was carried out using Xray diffractometers (XRD) and Infrared absorption spectrometry. In addition, this work
presents a new technique for the synthesis of biocompatible delaminated LDH (dLDH),
based on the use of propylene glycol. Through this method it was possible to trap
glutamine and DNA on the surface of dLDH.
Additionally, we describe the synthesis and characterization of a LDH-alginate
nanohydrid matrix, which is expected to have enhanced stability as compared to
crystalline or dLDH. In order to optimize the synthetic process of the matrix we conducted
morphological studies using optical microscopy. In addition, drug release assays were
conducted simulated plasma serum. The process which was also performed for the LDHNitrofurantoin nanohybrid.
It is expected that these new approaches can be used as a basis for the synthesis of
more stable, safer and more selective drug carriers, while greatly reducing the cost of
synthesis and increasing shelf life.
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Language |
Greek |
Subject |
Aminoacids |
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DNA |
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Drug Delivery |
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Gene therapy |
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Glutamine |
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Layered double hydroxides (LDH) |
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Nanohybrids |
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Nitrofurantoin |
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Sodium Alginate |
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Sodium Cholate |
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Αλγινικό νάτριο |
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Αμινοξέα |
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Γλουταμίνη |
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Γονιδιακή Θεραπεία |
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Μεταφορά φαρμάκων |
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Νανοϋβρίδια |
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Νιτροφουραντοΐνη |
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Στοιβαγμένα διπλά υδροξείδια (LDH) |
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Χολικό νάτριο |
Issue date |
2020-03-27 |
Collection
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School/Department--School of Sciences and Engineering--Department of Chemistry--Graduate theses
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Type of Work--Graduate theses
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Permanent Link |
https://elocus.lib.uoc.gr//dlib/0/3/4/metadata-dlib-1585650734-129832-18297.tkl
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Views |
449 |