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Title DNA/αιμία από HSV, CMV, EBV και HHV8 σε HIV-1 ενήλικες. Συσχέτισή της με την ανταπόκριση στη HAART
Alternative Title Research of the effect of herpetic DNA/AEMIA from HSV1 and 2 CMV, EBV and HHV8 on the response to HAART in HIV-1 patients who initiate antiretroviral therapy
Author Παναγιωτάκης, Συμεών
Thesis advisor Σπαντίδος, Δημήτριος
Reviewer Τσατσάκης, Αριστείδης
Τσατσάνης, Χρήστος
Σαμώνης, Γεώργιος
Ζαφειρόπουλος, Α.
Σουρβίνος, Γεώργιος
Abstract The purpose of this study was to assess the qualitative single and multiple herpes virus DNAemia in the Peripheral Blood Leukocytes (PBLs) of HIV-1-positive patients and its impact on the response to highly active antiretroviral therapy (HAART) and immune reconstitution. All (163) HIV-1-positive patients attending &ldquo;Syngros AIDS Referral Center&rdquo; from November 2000 - February 2001 were recruited. CMV, HSV-1, HSV-2, EBV and HHV-8 DNA was detected in PBLs by Polymerase Chain Reaction technique (PCR). Patients’ follow-up comprised regular measurements of CD4+ T-cell count and HIV-1 viral load (VL) for an average period of 21 months. Immune reconstitution was defined as an increase in the CD4 T cell count by above 200 cells/μl, while response to HAART was defined as a decrease in HIV-1 VL to undetectable levels. Single and multiple herpetic DNAemia in PBLs was found to be significantly higher in HIV-1-positive patients compared to healthy controls (P<0.02) for all the viruses detected apart from HSV-2, which was not detected in the PBLs of either population. Concurrent CMV and EBV DNAemia significantly correlates with a delay in the response to HAART (P=0.033) in treatment-na&iuml;ve patients. Untreated patients with CD4+ T-cell count<200 cells/μl, and with CMV DNAemia, presented a delayed increase in CD4 count after HAART initiation (P=0.035), while multiple herpetic DNAemia in the above patients was borderline associated with immune reconstitution (P=0.068). Conclusively CMV and EBV DNAemia may be a poor prognostic factor for the response to HAART in treatment na&iuml;ve HIV-1 patients.
Language Greek
Subject Virology
Issue date 2007-03-08
Collection   Faculty/Department--School of Medicine--Department of Medicine--Doctoral theses
  Type of Work--Doctoral theses
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