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Identifier	uch.biology.phd//2002katsantoni
Title	Διερεύνηση του ρόλου των cis-ρυθμιστικών στοιχείων του συμπλέγματος των β-γονιδίων της σφαιρίνης, στη μεταστροφή της αιμοσφαιρίνης με invitro και in vivo λειτουργικές μελέτες
Alternative Title	Identification of the role of cis-acting elements of the β-globin gene cluster, in the hemoglobin switching with in vitro and in vivo functional assays
Author	Κατσαντώνη, Ελένη Ζ
Thesis advisor	Ανάγνου, Νικόλαος
Abstract	The specific aims of this PhD thesis were focused on (1) the identification of the role of the elements Enh, F, O, P, S, U, M, Μ1 and Μ2, and of the synergistic role of Εnh+F and O+P in the expression of the luciferase reporter gene, by using transient transfection assays in erythroid and non erythroid cells, (2) the identification of the role of the elements Enh and F in transgenic mice, by deleting them via homologous recombination, and (3) the identification of the role of the HPFH-2, HPFH-3 and HPFH-6 enhancers in transgenic mice.
Language	Greek
Subject	Αιμοσφαιρίνες; Γονίδια σφαιρινών; Μεταστροφή αιμοσφαιρίνης; Ενισχυτές; Αποσιωπητές; Διαγονιδιακοί ποντικοί; Αιμοσφαιρινοπάθειες; Ομόλογος ανασυνδυασμός
Issue date	2002-06-18
Collection	School/Department--School of Sciences and Engineering--Department of Biology--Doctoral theses
	Type of Work--Doctoral theses
Permanent Link	https://elocus.lib.uoc.gr//dlib/8/a/3/metadata-dlib-2002katsantoni.tkl
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