Your browser does not support JavaScript!

Home    Search  

Results - Details

Search command : Author="Ραϊσάκη"  And Author="Μαρία"

Current Record: 5 of 21

Back to Results Previous page
Next page
Add to Basket
[Add to Basket]
Identifier 000447556
Title Όγκοι ΚΝΣ σε παιδιά, εφήβους και νεαρούς ενήλικες : Επιδημιολογία, θεραπεία, πρόγνωση. Εμπειρία 25 ετών Κλινικής Αιματολογίας-Ογκολογίας Παίδων ΠαΓΝΗ και νεότερα βιβλιογραφικά δεδομένα
Alternative Title CNS tumors in children, adolescents and young adults.
Author Μπαχλιτζανάκη, Μαρία Ν.
Thesis advisor Στειακάκη, Ευτυχία
Reviewer Ραϊσάκη, Μαρία
Βάκης, Αντώνιος
Abstract Introduction: Primary tumors of the central nervous system (CNS) in children, adolescents and young adults are concerned rare (~1%) but remain the most common solid malignancy and the 2nd most frequent following leukaemia in this age group representing about 15-20% of total tumors. They are considered as the 1st cause of death between paediatric patients and are responsible for ~2% of deaths because of cancer. Prognosis and clinical symptoms derive from various factors related with site and tumor development rate, age of diagnosis, histology and molecular identity of the tumor. This heterogenous tumor group is categorized based on location whereas the tremendous latest advances in research of molecular landscape revealed further subtypes according to current international WHO classification and promising diagnostic and therapeutic perspectives based on targetable pathways. During the past decades, surgical removal in combination with conventional chemotherapy and radiotherapy was the preferable treatment for CNS tumors. Nowadays, precision medicine with novel targeted therapies holds significant promise. CNS tumors appear with specific age and racial distribution. A variety of epidemiologic, genetic and environmental predisposition and risk factors have been identified, for their occurrence. These variables are correlated with higher mortality comparing to other malignancies despite medical progress in diagnostic and therapeutic field. Effective management demands a multidisciplinary medical team. Late complications should be taken under consideration and children treated for CNS tumors should be closely followed up into adolescence and adulthood. Aim: A retrospective record of children, adolescents and young adults admitted and treated for CNS tumors in Pediatric Hematology and Oncology Department of University General Hospital of Heraklion, the correlation of demographic and clinical features, available histology and molecular characteristics of each tumor, treatment approach, response or remission for every individual, complications or side effects (proximal or distal) with final outcome compared to data recorded bibliographically. Materials and methods: This record includes all the subgroups of CNS tumors according to the international WHO classification of patients admitted and treated in Pediatric Hematology and Oncology Department of University General Hospital of Heraklion during the last 25 years. Demographic features of patients (age, sex and race) and their clinical presentation at the time of diagnosis were recorded. Available histological and molecular tumor features, selected treatment stratification and significant milestones for response or remission were also recorded for every individual according to their personal medical report. Furthermore, complications and adverse events (proximal or distant) are categorized and final outcome is recorded according to the last patients` medical follow up. The results of statistical analysis of gathered information were compared to accurate bibliography data. Results: The research included 81 patients (43 female and 38 male) with CNS tumor of median age of diagnosis 6,92 ± 4,52 years. The median total monitoring time was 52,15 ± 63,47 months, 38 patients (46,91%) were under observation, 5 (6,17%) were under treatment and 32 (39,51%) passed away. The median age of diagnosis and the incidence of most commonly recorded neoplasms was in accordance to bibliographic data with an exception observed in optic pathway/hypothalamic LGGs and MB (18,51% and 37,8% versus 3-5% and 25% perspectively). 5-year overall survival for MB was also different (63,64% versus >75%), fact that could be imputed to the size of sample. For patients with CNS tumors 5-year event free survival was 42,5% and 5-year overall survival was 50,9%. Conclusion: Treatment of patients with CNS tumors of this department was according to international corresponding treatment stratification protocols. Exported results were in agreement with those referred bibliographically and differences found were attributed to record limitations and medical progress achieved through last decades. The continuation of long-term recording could make the sample more reliable and will lead to safer conclusions. The study of new molecular parameters is of great importance and prognostic value and can conclude in more accurate staging of the disease.
Language Greek
Subject Central nervous system tumors
Paediatric patients
Όγκοι κεντρικού νευρικού συστήματος
Παιδιατροί ασθενείς
Issue date 2022-03-30
Collection   School/Department--School of Medicine--Department of Medicine--Post-graduate theses
  Type of Work--Post-graduate theses
Permanent Link https://elocus.lib.uoc.gr//dlib/5/f/c/metadata-dlib-1649830225-107770-19741.tkl Bookmark and Share
Views 289

Digital Documents
No preview available

No permission to view document.
It won't be available until: 2025-03-30