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Identifier

000375790

Title

The role of p75 neurotrophin receptor in the nervous system:a structure-function study

Alternative Title

Μελέτες δομής-δράσης του υποδοχέα νευροτροφίνων p75 στο νευρικό σύστημα

Author

Pediaditakis Iosif.

Author

Πεδιαδιτάκης Ιωσήφ.

Thesis advisor

Γραβάνης, Αχιλλέας

Abstract

The p75 neurotrophin receptor (p75NTR) was the first neurotrophin receptor discovered which can essentially bind to all neurotrophins with equal affinity. Recent studies have shown that it can also bind to the pro-form of NGF with a higher affinity than its mature form. p75NTR is capable of interacting with an increasing list of co-receptors (including Trk, Nogo and Lingo) and endocytoplasmic proteins, apparently by a variety of different mechanisms. Many of the effectors identified have been implicated in cell cycle regulation, apoptosis, or both, suggesting pleiotropic roles for p75NTR during development. By using genetic analysis of distinct sets of exposed residues in the intracellular domain that can selectively interfere with the activation of p75NTR signaling pathways, we tried to identify the exact receptor domains capable of activating some pathways but not others, resulting in distinguishing the multiple functions of the receptor in the Nervous System.

Language

Greek

Subject

Apoptosis

Nervous system Neurotrophin

P75 receptor

Απόπτωση

Νευρικό σύστημα

Υποδοχέας P75

Issue date

2010-07-20

Collection