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Identifier 000454755
Title Εκτίμηση μυϊκής ισχύος και αναπνευστικής λειτουργίας μετά από λοίμωξη Covid-19
Alternative Title Assessment of post-Covid -19 muscular strength and respiratory function
Author Κουκιάς, Στέργος
Thesis advisor Μπριασούλης, Γεώργιος
Reviewer Ηλία, Σταυρούλα
Κονδύλη, Ευμορφία
Abstract Background: A large proportion of patients infected with COVID-19 virus, complaint of symptoms even 12 weeks after the acute phase of the infection. Shortness of breath and weakness seem to be the most common. The pathogenic mechanism and risk factors of post-COVID-19 syndrome are not well understood. The assessment and monitoring of patients with this particular syndrome is of vital importance for addressing symptoms and improving quality of life. Objective: The purpose of this study is to assess muscular strength and respiratory function 1 to 6 months after COVID-19 infection in patients with mild, moderate, severe, or critical illness. Methods: In this prospective cohort study, patients with laboratory-confirmed COVID-19 were enrolled and evaluated 1 to 6 months after the disease during the period June 2022 to December 2022. Specifically, demographic data, past medical history, vaccination status, duration of illness, chest imaging and post-COVID-19 symptoms were recorded. Spirometry was used to evaluate respiratory function and hand dynamometer was used to assess muscular strength. Parametric and non-parametric tests were used for statistical analysis of the data, depending on the variables under examination. Results: A total of 250 patients, who recovered from COVID-19, were included. The patient had a median age of 50,416,3 years and 137 were women. The disease severity ranged in the vast majority from mild (65.2%) to severe (23.2%), with only 2% of patients being asymptomatic and 2% being critically ill. In the first month of the evaluation, most patients (84,4%) reported post-COVID-19 symptoms. The most frequently reported symptoms in patients with severe disease were dyspnea and fatigue. A proportion of the total number of patients (n=71, 28.4%) were evaluated by spirometry. Patients with moderate to critical disease severity (p=0.014), as well as patients who needed to be hospitalized in a COVID-19 medical ward or Intensive care unit (p<0.001), had significantly higher risk rates of obstructive or restrictive lung disease. Hand grip strength was found significantly reduced in patients with comorbidities (p=0,001) and patients reporting post-COVID symptoms 6 months after illness (p=0,047). Conclusion: Follow-up and management of post-COVID patients is a challenge for healthcare providers, as it requires a multidisciplinary approach. Impairment in respiratory function and muscular weakness are frequently found in these patients related to the severity of illness and the presence of comorbidities. Further research is needed on the consequences of post- COVID-19 syndrome, as well as on the management of these patients, with the aim of improving their quality of life.
Language Greek
Subject Spirometry
Δυναμόμετρο
Σπυρομέτρηση
Issue date 2023-04-05
Collection   School/Department--School of Medicine--Department of Medicine--Post-graduate theses
  Type of Work--Post-graduate theses
Permanent Link https://elocus.lib.uoc.gr//dlib/a/f/4/metadata-dlib-1682488274-30540-14736.tkl Bookmark and Share
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