Results - Details
Search command : Author="Ρίζος"
And Author="Απόστολος"
Current Record: 6 of 27
|
|
| Title |
Διερεύνηση και συσχέτιση της επιβάρυνσης μητέρας-νεογνού σε ουσίες με πιθανή ενδοκρινική δράση |
| Alternative Title |
Investigating and correlating the maternal-neonatal burden on substances with possible endocrine activity |
|
Author
|
Τσαγγαρίδου, Στέφανη
|
|
Thesis advisor
|
Ρίζος, Απόστολος
Τζατζαράκης, Εμμανουήλ
|
| Abstract |
Endocrine disruptors are substances that can be found everywhere in our daily life making
almost impossible the avoidance of contacting with them. Endocrine disruptors are
exogenous compounds or mixtures of compounds that can cause adverse effects on the
health of an organism or its progeny. These effects are due to changes that are caused in
endocrine function. Children, especially new-borns, are more sensitive to these substances
than adults because metabolic pathways are incomplete during the first months of life. Newborns’ system metabolizes, detoxifies and eliminates unwanted substances in a different way
than adults do, resulting in being more vulnerable to health problems.
Current study aimed to evaluate the levels of DTTs, Parabens, Triclosan (TCS) and Bisphenols
A, S in both maternal and neonatal hair and examine whether there are any correlations
between them. In addition, the changesin the children’s’ burden aged 6-12 months were also
evaluated.
Hair samples were collected from 39 mothers and 44 newborns. Two samples were collected
from some of the newborns. The first sampling was obtained immediately after the birth and
the second sampling was obtained between the 6th to 12th months of age (12 children). The
hair samples were recorded in accordance with their length, weight and colour.
Solid-liquid extraction with methanol was used for samples processing. For the analysis of
parabens, bisphenols and TCS liquid chromatography (LC) coupled with mass spectrometry
(MS) were utilized. As for organochlorinated substances (DDTs, HCB), a gas chromatography
(GC) coupled with mass spectrometry (MS) were used.
Hair sample analysis revealed that MenPB, ProPB, TCS and ppDDE had higher positivity rates
90-100%, than op DDD and ppDDD + op DDT which had lower rates with 0-30%. The burden
was evident since the concentrations of lipophilic compounds (TCS, DDE, DDD, DDT, HCB)
were increased in newborns samples compared to the samples obtained from the mothers
and children. At the same time, parabens concentration levels in mothers’ samples were
higher while those of bisphenols were higher in children's samples 6th to 12th months of age
|
| Language |
Greek |
| Issue date |
2021-07-30 |
| Collection
|
School/Department--School of Sciences and Engineering--Department of Chemistry--Graduate theses
|
|
|
Type of Work--Graduate theses
|
| Permanent Link |
https://elocus.lib.uoc.gr//dlib/e/3/0/metadata-dlib-1625640585-281289-16401.tkl
|
| Views |
293 |
|
Digital Documents
|
|
No permission to view document.
It won't be available until: 2024-07-30
|
Search
