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Identifier 000454151
Title Έκφραση-καθαρισμός της πρωτεΐνης KRas-4b G12C και ανάπτυξη ομοιοπολικών αναστολέων της
Alternative Title Expression and purification of KRas-4b G12C and development of its covalent inhibitors
Author Φωτιάδη, Αλίκη Γ.
Thesis advisor Νεοχωρίτης, Κωνσταντίνος
Reviewer Γκουρίδης, Γεώργιος
Σμόνου, Ιουλία
Abstract Cancer therapy has always been a great challenge for humanity and science. The search for bioactive small molecules continues throughout the years always aiming on more efficient drugs. It has been demonstrated that many different forms of cancer are linked to the G12C mutation of KRas-4b protein. Thus, in the present master thesis, the design and synthesis of covalent inhibitors based on 2-amino substituted thiophene derivatives via the Gewald reaction, a multicomponent reaction (MCR), was performed. In addition, the expression and purification of the protein KRas-4b (G12C) was successfully accomplished. This enabled the evaluation of the newly synthesized compounds of the covalent inhibition of the KRas-4b through mass spectrometry, by binding to the cysteine residue irreversibly.
Language Greek, English
Subject Covalent inhibitors
Gewald reaction
multi-component reactions
Αντίδραση Gewald
Αντιδράσεις πολλών συστατικών
Ομοιοπολικοί αναστολείς
Issue date 2023-03-30
Collection   School/Department--School of Sciences and Engineering--Department of Chemistry--Post-graduate theses
  Type of Work--Post-graduate theses
Permanent Link https://elocus.lib.uoc.gr//dlib/2/4/e/metadata-dlib-1678093567-869026-14787.tkl Bookmark and Share
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