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Identifier

000447919

Title

Computational modeling of the trisynaptic circuit DG/CA3/CA1

Alternative Title

Υπολογιστική μοντελοποίησητου τρισυναπτικού δικτύου DG/CA3/CA1

Author

Χατζησάββας, Αλέξανδρος

Thesis advisor

Ποϊράζη, Παναγιώτα

Reviewer

Χαραλαμπόπουλος, Ιωάννης
Βενυχάκη, Μαρία

Abstract

The Hippocampus plays a key role in numerous brain processes such as episodic memory formation and recall, and spatial navigation. Multiple streams of previously unrelated information converge to the hippocampal circuits where important mnemonic functions such as pattern separation and pattern completion take place. Some of the primary hippocampal areas include the DG, CA3, and CA1, which comprise the so-called trisynaptic pathway, a closed processing loop with bidirectional connections with higher cortical areas. Computational modeling has been extensively utilized to understand how hippocampal network dynamics are linked to behavior since such studies often require experiments that are restricted by technical limitations. However, most currently available Hippocampus models are often overly simplistic, ignoring key neuronal and network properties. Importantly, they overlook the implications of active dendritic mechanisms to network-level functions. For this reason, we developed a simplified yet biologically plausible network model of the trisynaptic pathway, which was extensively validated against experimental data. Our network model accurately reproduces many essential cellular and network functions, along with their contribution to pattern separation and pattern completion. To our knowledge, this is the first hippocampal model of the complete trisynaptic pathway that also incorporates active dendritic properties and highly sophisticated connectivity. Hence, our model offers a flexible experimentation platform for exploring how single-cell properties, such as dendritic computations and plasticity, or neuronal network properties like inhibition and network connectivity affect hippocampal dynamics and well-known memory processes.

Language

English

Subject

Dendrites

Dendritic spikes

Dentate Gyrus

Hippocampus

Interneurons

Issue date

2022-03-30

Collection

School/Department--School of Medicine--Department of Medicine--Post-graduate theses