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Identifier 000448741
Title Ανάλυση βακτηριακών γονιδιωμάτων και εκκρινόμενων πρωτεϊνικών τελεστών για την μελέτη των μοριακών μηχανισμών παθογένειας της Ξανθομονάδας
Alternative Title Analysis of bacterial genomes and secreted effector proteins for the study of molecular mechanics of Xanthomonas pathogenicity
Author Μιχαλοπούλου, Βασιλική Α
Thesis advisor Σαρρής, Παναγιώτης
Reviewer Καλαντίδης, Κρίτων
Κοτζαμπάσης, Κυριάκος
Μόσχου, Παναγιώτης
Σκούλικα, Ευσταθία
Παυλίδης, Ιωάννης
Τραντάς, Εμμανουήλ
Abstract Intensive research during the past years has been made to elucidate the molecular mechanisms of pathogens' interaction with their hosts, in plant disease. The research focuses both on understanding of basic pathogenic mechanisms of microorganisms and on the host responses, developed as a counter-defense. Sequencing of more bacterial genomes in the last five years leads to a better understanding in depth of the molecular mechanisms of host-pathogen interactions. This doctoral dissertation is divided in two chapters. In the first and more extended chapter of this work, new interactions between bacterial pathogens and their potential host targets are presented. Furthermore, the results of the analysis of a pair of interaction are shown. In particular, we show that the exocyst component EXO70B1 of Arabidopsis thaliana is a specific target of XopP, which is a conserved type-III effector of Xanthomonas campestris pv. campestris. Next, our findings regarding the virulence mechanisms of XccXopP are analyzed in depth. This effector appears to suppress the host’s basal defense (PTI), through interacting with various members of the exocyst complex, without activating the host’s specific defense (ETI). The second chapter presents the results of full-genome sequencing of three type strains bacteria of genus Xanthomonas. Specifically, the characteristics found in the genomes of Xanthomonas oryzae pv. oryzicola, Xanthomonas hortorum pv. hederae and Xanthomonas citri subsp. malvacearum are shown. All three sequenced bacteria appear to encode for most of the conserved type-III effectors, as well as structural and secreted proteins of the secretory apparatuses of type I, II, IV and VI.
Language Greek
Subject NLR-ID
Βακτηριακά γονιδιώματα
Βακτηριακές πρωτεΐνες παθογένειας
Issue date 2022-06-08
Collection   School/Department--School of Sciences and Engineering--Department of Biology--Doctoral theses
  Type of Work--Doctoral theses
Permanent Link https://elocus.lib.uoc.gr//dlib/7/b/6/metadata-dlib-1654160922-43816-8167.tkl Bookmark and Share
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