Results - Details
Search command : Author="Σαμώνης"
And Author="Γεώργιος"
Current Record: 73 of 84
|
Identifier |
000347788 |
Title |
Μορφές καρδιοτοξικότητας σε ογκολογικούς ασθενείς υπό χημιοθεραπεία και η σχέση τους με την ανίχνευση κυτοκινών και αποπτωτικών ογκογονιδίων |
Author
|
Κουλουμπίνης, Αλέξανδρος Κ
|
Thesis advisor
|
Γεωργούλιας, Βασίλειος
|
Reviewer
|
Μαυρουδής, Δ
Παρθενάκης, Φραγκίσκος
Σαμώνης, Γεώργιος
Βάρδας, Παναγιώτης
Σταθόπουλος, Ε
Αγγελάκης, Σ
|
Abstract |
In recent years, a tremendous progress has been made, concerning treatment, in reducing the morbitidy and mortality of many forms of cancer. Many of these treatments have important potential adverse cardiac effects and are likely to have significant effects on patients outcomes. Many cancer survivors will actually be at as great risk from cardiac disease, as from recurrent cancer. It is therefore critical for cancer survivors to limit comorbid illnesses.
The anthracycline cardiotoxicity is cumulative, dose-related and at sufficiently high dosages, can result in congestive heart failure (CHF) and left ventricular (LV) dysfunction. The experience with anthracycline cardiotoxicity proved that the early detection and treatment of cardiotoxicity could significantly diminish the clinical manifestations.
In the present study, an effort has been made to detect early asymptomatic cardiac dysfunction in breast cancer patients, by measuring the circulating levels of proinflammatory cytokines, sFas/Fas ligand system and natriuretic peptides, before and right after the completion of cardiotoxic chemotherapy.
These proteins might be used as reliable and sensitive diagnostic indices in the early detection and treatment of asymtomatic LV dysfunction, before the onset of symptoms. It is of great importance to reduce the risk from cardiac disease, to limit the comorbidities and to imrove the quality of life of the cancer survivors.
|
Language |
Greek |
Subject |
Breast Neoplasms |
|
Cardiovascular Diseases chemically induced |
|
Drug Toxicity |
|
Neoplasms drug therapy |
|
Μαστού νεοπλάσματα |
|
Φαρμάκων τοξικότητα |
Issue date |
2007-12-14 |
Collection
|
School/Department--School of Medicine--Department of Medicine--Doctoral theses
|
|
Type of Work--Doctoral theses
|
Permanent Link |
https://elocus.lib.uoc.gr//dlib/5/e/d/metadata-dlib-98f8a9a7dbe94f0866270e31d4c373eb_1247727873.tkl
|
Views |
387 |