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Identifier

000347788

Title

Μορφές καρδιοτοξικότητας σε ογκολογικούς ασθενείς υπό χημιοθεραπεία και η σχέση τους με την ανίχνευση κυτοκινών και αποπτωτικών ογκογονιδίων

Author

Κουλουμπίνης, Αλέξανδρος Κ

Thesis advisor

Γεωργούλιας, Βασίλειος

Reviewer

Μαυρουδής, Δ
Παρθενάκης, Φραγκίσκος
Σαμώνης, Γεώργιος
Βάρδας, Παναγιώτης
Σταθόπουλος, Ε
Αγγελάκης, Σ

Abstract

In recent years, a tremendous progress has been made, concerning treatment, in reducing the morbitidy and mortality of many forms of cancer. Many of these treatments have important potential adverse cardiac effects and are likely to have significant effects on patients outcomes. Many cancer survivors will actually be at as great risk from cardiac disease, as from recurrent cancer. It is therefore critical for cancer survivors to limit comorbid illnesses. The anthracycline cardiotoxicity is cumulative, dose-related and at sufficiently high dosages, can result in congestive heart failure (CHF) and left ventricular (LV) dysfunction. The experience with anthracycline cardiotoxicity proved that the early detection and treatment of cardiotoxicity could significantly diminish the clinical manifestations. In the present study, an effort has been made to detect early asymptomatic cardiac dysfunction in breast cancer patients, by measuring the circulating levels of proinflammatory cytokines, sFas/Fas ligand system and natriuretic peptides, before and right after the completion of cardiotoxic chemotherapy. These proteins might be used as reliable and sensitive diagnostic indices in the early detection and treatment of asymtomatic LV dysfunction, before the onset of symptoms. It is of great importance to reduce the risk from cardiac disease, to limit the comorbidities and to imrove the quality of life of the cancer survivors.

Language

Greek

Subject

Breast Neoplasms

Cardiovascular Diseases chemically induced

Drug Toxicity

Neoplasms drug therapy

Μαστού νεοπλάσματα

Φαρμάκων τοξικότητα

Issue date

2007-12-14

Collection