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Identifier

000438268

Title

Εμβολιαστική κάλυψη ασθενών με λοίμωξη HIV στην Κρήτη

Alternative Title

Vaccination coverage of patients with HIV on Crete

Author

Duijker George

Thesis advisor

Κοφτερίδης, Διαμαντής

Reviewer

Γαλανάκης, Εμμανουήλ
Τσιλιγιάννη, Ιωάννα

Abstract

Introduction: Although the introduction of antiretroviral therapy (ART) has significantly contributed to improving the quality of life and life expectancy of people living with HIV (PLWHIV), they are at a greater risk of infections compared to the healthy population, which could be prevented with vaccination. The aim of the study is to examine the extent to which the vaccination coverage has been achieved for adults who are monitored at the special infection clinics of the 7th Health District of Crete. Methodology: Data were collected from the medical records of the patients with HIV who visit the special infection clinics. Data were collected on socio-demographic data, patients' co-morbidity, their immune status (CD4 +, CD4 + / CD8 +, viral load), as well as the vaccines they had received. Results: Data were collected from 382 patients of which 304 were men (79.1%), the mean age was 47.6 years and the majority did receive ART (368 persons, 96.3%). The mean CD4 + cell count and the CD4 + / CD8 + ratio were respectively 319.3 and 0.40, when they had been diagnosed initially with HIV infection and it was found to be elevated at the last recorded screening with the mean CD4 + count being 618.3 and the CD4 + / ratio CD8 + at 0.91. The flu vaccine was given to 108 (28.3%), 136 (35.6%), 192 (50.3%) patients with HIV for the respective years 2018, 2019 and 2020. For pneumococcal vaccination, 235 people (61.5%) were vaccinated with the conjugated vaccine and 196 patients (51.3%) with the polysaccharide vaccine. Hepatitis A and B vaccination was given to 16 (4.2%) and 187 (49%) individuals, respectively. A booster dose of tetanus - diphtheria was given to 17 people (4.5%) and the shingles vaccine was given to 5 patients out of 52 people in the study population who were at least 60 years old (9.6%). Greek patients and those with insurance capacity were associated with vaccinations against influenza, Streptococcus Pneumoniae (PCV-13) and hepatitis B (p <0.001). The hepatitis Β vaccine was associated with young PLWHIV aged 20 - 39 years (p = 0.005), while the vaccines against influenza and Streptococcus Pneumoniae. (PCV-13) were associated with individuals who were at least 60 years old (p≤0.001). Also a positive correlation was found with the educational level for the conduction of preventive vaccination (p= 0.001). Conclusion: Although there is a significant improvement and restoration of the immune system of PLWHIV, the vaccination coverage rates for preventable diseases were found to be relatively insufficient and there is still room for improvement. Foreign patients and those without insurance coverage appear to have lower compliance with vaccination.

Language

Greek

Subject

AIDS

Influenza

Streptococcus Pneumoniae

Γρίπη

Εμβολιασμός

Ηπατίτιδα Β

Πνευμονιόκκοκος

Issue date

2021-03-29