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Identifier |
000448741 |
Title |
Ανάλυση βακτηριακών γονιδιωμάτων και εκκρινόμενων πρωτεϊνικών τελεστών για την μελέτη των μοριακών μηχανισμών παθογένειας της Ξανθομονάδας |
Alternative Title |
Analysis of bacterial genomes and secreted effector proteins for the study of molecular mechanics of Xanthomonas pathogenicity |
Author
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Μιχαλοπούλου, Βασιλική Α
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Thesis advisor
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Σαρρής, Παναγιώτης
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Reviewer
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Καλαντίδης, Κρίτων
Κοτζαμπάσης, Κυριάκος
Μόσχου, Παναγιώτης
Σκούλικα, Ευσταθία
Παυλίδης, Ιωάννης
Τραντάς, Εμμανουήλ
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Abstract |
Intensive research during the past years has been made to elucidate the
molecular mechanisms of pathogens' interaction with their hosts, in plant
disease. The research focuses both on understanding of basic pathogenic
mechanisms of microorganisms and on the host responses, developed as a
counter-defense. Sequencing of more bacterial genomes in the last five
years leads to a better understanding in depth of the molecular mechanisms
of host-pathogen interactions.
This doctoral dissertation is divided in two chapters. In the first and more
extended chapter of this work, new interactions between bacterial
pathogens and their potential host targets are presented. Furthermore, the
results of the analysis of a pair of interaction are shown. In particular, we
show that the exocyst component EXO70B1 of Arabidopsis thaliana is a
specific target of XopP, which is a conserved type-III effector of
Xanthomonas campestris pv. campestris. Next, our findings regarding the
virulence mechanisms of XccXopP are analyzed in depth. This effector
appears to suppress the host’s basal defense (PTI), through interacting with
various members of the exocyst complex, without activating the host’s
specific defense (ETI).
The second chapter presents the results of full-genome sequencing of three
type strains bacteria of genus Xanthomonas. Specifically, the
characteristics found in the genomes of Xanthomonas oryzae pv. oryzicola,
Xanthomonas hortorum pv. hederae and Xanthomonas citri subsp.
malvacearum are shown. All three sequenced bacteria appear to encode for
most of the conserved type-III effectors, as well as structural and secreted
proteins of the secretory apparatuses of type I, II, IV and VI.
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Language |
Greek |
Subject |
NLR-ID |
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Βακτηριακά γονιδιώματα |
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Βακτηριακές πρωτεΐνες παθογένειας |
Issue date |
2022-06-08 |
Collection
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School/Department--School of Sciences and Engineering--Department of Biology--Doctoral theses
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Type of Work--Doctoral theses
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Permanent Link |
https://elocus.lib.uoc.gr//dlib/7/b/6/metadata-dlib-1654160922-43816-8167.tkl
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Views |
442 |