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Identifier 000412968
Title Σύνθεση και χαρακτηρισμός νανοβιοϋβριδίων LDH (στοιβαγμένων διπλών υδροξειδίων)
Alternative Title Synthesis and characterization of LDH (Layered Double Hydroxide) nanobiohybrids
Author Σφενδουράκης, Γεώργιος-Παναγιώτης Κ.
Thesis advisor Γανωτάκης, Δημήτριος Φ.
Reviewer Τσιώτης, Γεώργιος
Χανιωτάκης, Νικόλαος
Abstract The aim of this thesis has been the synthesis and characterization of layered double hydroxides (LDH) nanohybrids containing various organic substances within the layers of LDH. The nanohybrids described in this project were chosen based on their biological applications for drug delivery or photodynamic treatment. Emphasis was given on the synthesis and characterization of an LDH nanohybrid containing protoporphyrin IX. LDH nanohybrids were prepared by using ion exchange, rehydration and coprecipitation techniques. The nanohybrids were subsequently characterized by employing the most commonly used analysis techniques, focusing on x-ray diffraction (XRD) and IR spectroscopy. Moreover, the rate of release and action of the trapped substance was studied. The ability of the LDH-ppIX hybrid to act as a photosensitizer to photooxidize cancerous cells was analyzed, and then compared to that of free protoporphyrin IX. The toxicity of pristine LDH was also investigated. Three methods of LDH delamination were studied for the preparation of a better drug carrier, while trying to determine the technique that offers the most advantages. Degradation was assayed by using dynamic light scattering and the drug import capabilities in these LDHs were then examined. Finally, the preparation of an LDH-DNA hybrid was investigated.
Language Greek
Subject Amino acids
Deoxyribonucleic acid (DNA)cholic acid
Drug delivery
Photodynamic therapy
Protoporphyrin ΙΧ (ppIX)
Δεοξυριβονουκλεϊκό οξύ (DNA)
Μεταφορά φαρμάκων
Νιτροφουραντοΐνη, αμινοξέα
Πρωτοπορφυρίνη ΙΧ (ppIX)
Φωτοδυναμική θεραπεία
Χολικό οξύ
Issue date 2017-11-23
Collection   School/Department--School of Sciences and Engineering--Department of Chemistry--Post-graduate theses
  Type of Work--Post-graduate theses
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