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Identifier	000444620
Title	Synthesis of biocompatible, pH-responsive and biodegradable polyesters
Alternative Title	Σύνθεση βιοσυμβατών, pH-αποκρίσιμων και βιοδιασπώμενων πολυεστέρων
Author	Μουντάκη, Στυλιανή Αφροδίτη Γ.
Thesis advisor	Στρατάκης, Μανώλης
Reviewer	Βαμβακάκη, Μαρία Χατζηνικολαΐδου, Μαρία
Abstract	Aliphatic polyesters have been extensively used in the biomedical field, for tissue engineering applications. Despite their numerous benefits, such as biocompatibility and biodegradability, these materials are mostly inert and lack specific functionalities that would provide them with extra biological and responsive characteristics, such as pH, temperature, mechanical stimuli etc., whereas the synthetic route followed usually requires multistep synthesis with strict conditions. In this work, pH-responsive aliphatic polyesters have been prepared by a facile condensation polymerization of a vinyl functionalized diol with a diacid chloride, followed by a carboxylic acidfunctionalization along the polymer chains, via a photo-induced thiol-ene click reaction. The postsynthesis functionalization was conducted using two different mercaptocarboxylic acids, namely 3-mercaptopropionic and thioglycolic acid allowing the variation of the alkyl chain length of the side pendant groups. Furthermore, by adjusting the irradiation period during the click reaction, the degree of modification, and hence the carboxylic acid content of the polymers, could be easily controlled. Both of these characteristics were shown to have a significant impact on the responsive behavior of the polyesters with adjustable pKa values and water solubilities. To assess the biological properties of the materials in vitro, thin film of the difunctional polyesters bearing both alkene and carboxylic acid moieties were prepared by chemically linking the pendant vinyl bonds of a silanized substrate with the polymers’ side groups. The polymeric thin films with the shorter alkyl chain and the highest functionalization degree (PE-Glyc50) were found to promote greatly the cell viability, proliferation, and attachment when assessed in L929 fibroblast cultures. Next the PE-Glyc50 polyester, as well as a blend of the same polyester with laponite, were blended with PEGDMA as the crosslinker, to develop stable 3D scaffolds via an extrusion-based printing method. Finally, the optimized printing conditions resulted in structures that were investigated for their degradability and the influence of the pH on their swelling behavior, porosity.
Language	English
Issue date	2022-03-31
Collection	School/Department--School of Sciences and Engineering--Department of Chemistry--Post-graduate theses
	Type of Work--Post-graduate theses
Permanent Link	https://elocus.lib.uoc.gr//dlib/d/b/3/metadata-dlib-1640183186-919077-12112.tkl
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