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Identifier

000446828

Title

Μελέτη πεπτιδικών υδρογελών για εφαρμογές ιστοτεχνολογίας

Alternative Title

Study of peptide hydrogels for tissue engineering applications

Author

Πετροπούλου, Αικατερίνη-Ισμήνη Σ.

Thesis advisor

Μητράκη, Άννα

Reviewer

Κοκκινίδης, Μιχαήλ
Βαμβακάκη, Μαρία

Abstract

The use of hydrogels as scaffolds for biomineralization has found a great application in both Tissue Engineering and Regenerative Medicine for the repair and treatment of many types of tissues. In the present work we studied peptide materials that are attached to protecting groups and which are self-assembled in biocompatible and stable nanostructures to be suitable for tissue enginnering applications. Specifically, the individual (Asp) aspartic residue is studied which has been shown to lead to the formation of well-ordered fibrous structures with two fluorenylmethoxycarbonyl (Fmoc) protecting groups or benzylcarboxyls one at the N-terminal and one at the carboxyl group. Therefore, many amino acid and small peptides which are modified with protecting groups have relatively fast self-assembly and exhibit remarkable physicochemical properties leading to three-dimensional (3-D) networks, trapping solvent molecules and forming hydrogels. In this case, the self-assembling fibrous structures are aimed at the ability to bind calcium and which will act as nucleation points for the binding of phosphate anions. The adhesion, proliferation and differentiation of prosteoblastic cells make the hydrogel a promising scaffold for tissue engineering and regenerative medicine.

Language

Greek

Subject

Biomineralization

Fibrils

Hydrogels

Self-assembly

Αυτοργάνωση

Βιοεναλάτωση

Ινίδια

Υδρογέλες

Issue date