Results - Details

Search command : Author="Βασιλικογιαννάκης"  And Author="Γεώργιος"

Current Record: 16 of 75

[Add to Basket]
Identifier	000446153
Title	Τοπικά αναισθητικά μέσω αντιδράσεων πολλών συστατικών
Alternative Title	Local anesthetics via multicomponent reactions
Author	Θωμαΐδη, Μαρία Θ.
Thesis advisor	Νεοχωρίτης, Κωνσταντίνος
Reviewer	Βασιλικογιαννάκης, Γεώργιος Σιδηροπούλου, Κυριακή
Abstract	Humanity has always been confronted with the sensation of pain, with anesthesia (general or local) being vital, forming the cornerstone for treating this sensation in surgeries and not only. Until now, the synthesis of the already known local anesthetics (LA) is carried out through several steps that require time, cost and effort, while at the same time it is necessary to find new local anesthetics with improved properties. Additionally, a big class of LA can be synthesized via the Ugi reaction (U3CR). Thus, in the present master thesis, an improved synthesis was performed of not only known and commercially available LAs, but new ones with different and diverse scaffolds in one step via multicomponent reactions-MCRs. Compounds related to the broader canal diseases were also synthesized. Next, the activity of certain derivatives synthesized as effective Na+ pump inhibitors in isolated slices of the hippocampal region of mice was studied.
Language	Greek
Subject	Aminoamides
	Na+ pump inhibitors
	Ugi reaction
	Αμινοαμιδικές ενώσεις
	Αναστολείς αντλίας Na+
	Αντίδραση Ugi
Issue date	2022-03-31
Collection	School/Department--School of Sciences and Engineering--Department of Chemistry--Post-graduate theses
	Type of Work--Post-graduate theses
Permanent Link	https://elocus.lib.uoc.gr//dlib/c/f/5/metadata-dlib-1645630499-782410-4515.tkl
Views	419

Digital Documents
	Download document View document Views : 1