E-Locus - Institutional Repository of the University of Crete

Home Search

Results - Details

Search command : Author="Σιδηρόπουλος" And Author="Πρόδρομος"

Current Record: 20 of 38

[Add to Basket]

Identifier

000414343

Title

Epidemiology of Systemic Lupus Erythematosus and Lupus Registry Establishment in Crete, Greece

Alternative Title

Επιδημιολογική μελέτη και οργάνωση της κοορτής συστηματικού ερυθηματώδους λύκου στην Κρήτη

Author

Γεργιανάκη, Ειρήνη Ν.

Thesis advisor

Μπερτσιάς, Γεώργιος

Reviewer

Σιδηρόπουλος, Πρόδρομος
Χατζή, Λήδα

Abstract

Objectives Several population-based surveillance studies on SLE have been reported, yet community-based, individual-case accessed, comprehensive reports are missing. Methods: We studied the SLE epidemiology and burden on the island of Crete during 1999-2013. Multisource case finding included patients ≥15 years old. Cases were ascertained by the ACR1997, SLICC2012 criteria, and rheumatologist diagnosis, and validated through synthesis of medical charts, administrative and patientgenerated data. Results: Overall age/sex-adjusted and crude incidence was 7.4 ([95% CI] 6.8-7.9) and 8.6 (8.0-9.0) per 100,000-persons/year, respectively, with stabilizing trends in women but increasing in men, and an average (±SD) age of diagnosis at 43 (±15) years. Adjusted and crude prevalence (December 2013) was 123 (114-133) and 143 (133- 154)/105, the latter being higher in urban than rural regions (165 versus 123/105, p<0.001). Age/sex-adjusted nephritis incidence was 0.6 (0.4-0.8) with stable trends, whereas that of neuropsychiatric SLE was 0.5 (0.4-0.7) per 100,000-person/years and increasing. Half of prevalent cases had moderate/severe manifestations, with 34% having received immunosuppressive/biologic therapy. After 7.2 (±6.6) years disease duration, 30.5% accrued damage with the neuropsychiatric domain most frequently afflicted, whereas 4.4% of nephritis patients developed end-stage renal disease. The ACR1997 and SLICC2012 classification criteria showed high concordance (87%), yet physician-based diagnosis occurred earlier than criteria-based in about 20% of cases. The total number of comorbidities was (mean ± SD) 3.4 ± 2.4 and 42% of SLE patients had multi-morbidity (>3 comorbidities) Conclusions: By employing a comprehensive methodology, we describe high SLE occurrence in Crete. Our results suggest that the disease is not rare, it affects predominantly middle-aged women and is increasingly recognized in men. Despite early diagnosis and treatment the clinical burden (irreversible damage, comorbidities) remains significant.

Language

Greek, English

Subject

Autoimmune disease

Epidemiology

Lupus nephritis

Neuropsychiatric lupus

Αυτοάνοσο νόσημα

Επιπολασμός

Νευροψυχιατρικός λύκος

Νεφρίτιδα ΣΕΛ

Issue date