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Identifier	000280493
Title	Στερεοεκλεκτική αναγωγή α-αλκυλο-1,3-δικετόνων και α-αλκυλο-β-κετο εστέρων καταλυόμενη από 20 απομονωμένες, Nadph-εξαρτώμενες, κετορεδουκτάσες
Alternative Title	Stereoselective reduction of OF α-alkyl-1,3-diketones and α-alkyl-β-keto esteres catalyzed by 20 isolated, nadph-dependent, ketoreductases
Author	Καλαϊτζάκης, Δημήτρης Νικολάου
Thesis advisor	Σμόνου, Ιουλία
Abstract	Optically active α-alkyl-β-hydroxy ketones and α-alkyl-β-hydroxy esters are important compounds in asymmetric organic synthesis, where they are used as building blocks for synthesis natural products and pharmaceuticals. They are of relatively small molecular weight, bear chirality at two stereogenic centers and contain at least two reactive functionalities (an alcohol, a ketone, and other reactive groups potentially present in the side chain of the substituent). For their synthesis we utilized twenty different isolated NADPH-dependent ketoreductases and the biocatalytic reduction of α-alkyl-1,3-diketones and α-alkyl-β-keto esters, via dynamic kinetic resolution, proved to be a highly efficient method for the preparation of these compounds.
Language	Greek
Subject	Biocatalysis
	Dynamic kinetic resolution
	Enzymatic reduction
	Hydroxy esters
	Hydroxy ketones
	Ketoreductases
	Βιοκατάλυση
	Δυναμικός κινητικός διαχωρισμός
	Ενζυμική αναγωγή
	Κετορεδουκτάσες
	Υδροξυ εστέρες
	Υδροξυ κετόνες
Issue date	2005-06-01
Collection	School/Department--School of Sciences and Engineering--Department of Chemistry--Post-graduate theses
	Type of Work--Post-graduate theses
Permanent Link	https://elocus.lib.uoc.gr//dlib/2/6/d/metadata-dlib-2005kalaitzakis.tkl
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