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Title

Synthesis of fluorinated protein-polymer conjugates via an oxygen tolerant copper catalyzed RDRP method

Author

Χατζηβασιλείου, Ευανθία

Thesis advisor

Βελώνια, Καλλιόπη

Abstract

Fluorinated polymers have already been applied in a variety of real life issues due to their unique chemical characteristics. However, their inherent properties also have some drawbacks and especially their solvophobicity causes significant problems on their use. Therefore, our laboratory is involved with the synthesis of a new class protein-fluorinated polymer bioconjugates targeting to more biological applications such as magnetic resolution imaging and drug delivery systems. The purpose of this thesis was to synthesize amphiphilic fluorinated polymer bioconjugates following new oxygen tolerant methods. A variety of fluorinated monomers were utilized for the development of different polymer chains onto the protein, following polymerization techniques catalyzed by copper that do not require the deoxygenation of the system (RDRP). In detail, two experimental approaches were followed, the single electron transfer - living radical polymerization (SET-LRP) and photo-induced living radical polymerization using UV lamp. The classical procedures were slightly altered through the use of syringe in order to limit the presence of oxygen and do not apply any deoxygenation procedure, simply by eliminating the reaction headspace. Our goal was to optimize the synthetic protocols, expand their use with new monomers and utilize 19F-NMR and IR spectroscopy for their characterization, in order to fully comprehend the properties of this new category of protein polymer conjugates .

Language

English

Issue date

2020-03-27

Collection

School/Department--School of Sciences and Engineering--Department of Chemistry--Graduate theses

Type of Work--Graduate theses

Views

524

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