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Identifier

000414379

Title

Investigating the role of dendrites in sparse representations in the hippocampus using computational models

Alternative Title

Διερεύνηση του ρόλου των δενδριτών του ιππόκαμπου σε μνημονικές διαδικασίες με χρήση υπολογιστικών μοντέλων

Author

Χαυλής, Σπυρίδων Σ.

Thesis advisor

Ποϊράζη, Παναγιώτα

Reviewer

Σιδηροπούλου, Κυριακή
Treves, Alessandro

Abstract

Memory formation, consolidation and recall are essential brain functions for ordinary life and these mnemonic processes are widely associated with hippocampus. Although hippocampus is a broadly studied brain region, both experimentally and computationally, the mechanisms underlie memory function remain a mystery. Hippocampus is widely hypothesized that involves in distinct mnemonic processes, such as pattern separation/completion and spatial encoding. Specifically, different regions accomplish the aforementioned tasks with dentate gyrus to be crucial for distinguishing overlapping memories, while CA1 subregion with spatial navigation and formation of the spatial map of the brain. Taking advantage of computational modeling, we implemented two different computational networks in order to reveal and study in-depth the mechanisms being key mediators during these functions. Our results indicate that sparsity is a key feature of dentate gyrus principal cells and we showed that various mechanisms could mediate this feature, such as the number of dendrites, the dendritic path-length as well as the mossy cells. In addition, we explored the role of each interneuron during spatial navigation. Our results show that each type of interneuron has a distinct role during place cell formation, with PV⁺ and VIP⁺/CCK⁺ basket cells being more critical. Our model generates a number of experimentally testable predictions that may lead to a better understanding of the physiological and pathological function of hippocampus.

Language

English

Subject

Memory

Δενδρίτες

Ιππόκαμπος

Μνήμη

Υπολογιστικά Μοντέλα

Issue date

2018-02-08

Collection

School/Department--School of Sciences and Engineering--Department of Biology--Doctoral theses