Graduate theses
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Current Record: 29 of 246
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Title |
Development of small molecule libraries for inhibition of ALOX15 enzyme |
Author
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Πολατίδου, Κατερίνα
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Thesis advisor
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Ελευθεριάδης Νικόλαος
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Abstract |
In this thesis libraries of small molecule for inhibition of 15-lipoxygenase type 1,
were designed. ALOX15 or 15-lipoxygenase type 1 enzyme, is implicated in many
serious diseases such as anaphylactic diseases, asthma, COPD, diabetes,
neurodegenerative diseases, certain types of cancer and many others due to the
production of pro- and anti-inflammatory metabolites. Because, the existing potent
15-lipoxygenase-1 inhibitors have undesirable properties, the aim of this thesis was
to find new scaffolds that possess good inhibitory potency. In order to achieve that,
we designed a library of compounds synthesized by medicinal chemistry groups and
organic chemistry groups that synthesize natural products. Also, a library of the
known inhibitors of ALOX15, with known activities was developed and used as a
control for our experiments. Then, docking studies were conducted using the rabbit
ortholog model of 15-lipoxygenase-1 (PDB-ID; 2P0M) to filter through these
compounds and propose the best ones to continue with in vitro inhibition studies.
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Language |
English |
Issue date |
2022-11-24 |
Collection
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School/Department--School of Sciences and Engineering--Department of Chemistry--Graduate theses
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Type of Work--Graduate theses
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Permanent Link |
https://elocus.lib.uoc.gr//dlib/0/e/2/metadata-dlib-1666682223-286741-28199.tkl
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Views |
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