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Doctoral theses

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Identifier

000032335

Title

Φθορίζοντες και Φωτομεταβαλλόμενοι δείκτες ιόντων. Σχεδιασμός και Συνθετικές προσεγγίσεις

Alternative Title

Eluorescent and Caged ion probes. Design and Synthetic approaches

Author

Φουκαράκη, Ευαγγελία Μ

Thesis advisor

Κατερινόπουλος, Χαράλαμπος

Abstract

In this thesis the preparation of four tetracarboxilic fluorescent calcium probes of BAPTA-type and the preparation of two tricarboxylic fluorescent ion probes, of APTRA-type is described. These syntheses are the result of extensive retrosynthetic analysis which took in consideration factors such as the affinity of the probes to the target ions, selectivity to the desired ion, optimization of optical properties of the probes as well as the possibility of cell permeability. Morover an extensive retrosynthetic analysis as well as a number of synthetic pathways aiming to the preparation of calcium caged compounds is presented. The thesis also includes preliminary studies of the fluorescent properties of the ion probes in the context of their use as potential intracellular ion probes.

Language

Greek

Subject

Λιπόφιλοι φθορίζοντες τετρακαρβοξυλικοί δείκτες

Τετρακαρβοξυλικοί δείκτες Ca

Φθορίζοντες

Φθορίζοντες τρικαρβοξυλικοί δείκτες

Φωτομεταβαλλόμενοι δείκτες

Issue date

1998-12-01

Collection

School/Department--School of Sciences and Engineering--Department of Chemistry--Doctoral theses