E-Locus - Institutional Repository of the University of Crete

Home Collections School/Department School of Medicine Department of Medicine Post-graduate theses

Post-graduate theses

Current Record: 876 of 1266

[Add to Basket]

Identifier

000378691

Title

Συνολική φαρμακευτική αγωγή ασθενών με ΧΑΠ και πιθανές αλληλεπιδράσεις

Alternative Title

Total medication of COPD patients and its potential drug interactions

Author

Λεντάρης, Ευάγγελος

Thesis advisor

Τζανάκης, Νικόλαος

Reviewer

Μοσχανδρέα, Ιωάννα

Abstract

Aim: Objective of this study was to investigate the total pharmaceutical treatment of COPD patients in East Crete. Added to this, detection of potential drug interactions as well as the type and the severity of their treatment were conducted. Methods: 68 COPD patients were the sample size. The ascertaining of the disease was made by spirometry in peripheral infirmaries and infirmaries of KAPI. Information concerning their medication was gathered from the patient’s health booklets, and an interview with the patient with a help of a health care professional resulted in completion of a questionnaire. The overall treatment and its interactions were recorded and detected through the completed questionnaires. Results: The subjects involved in this study, were mainly administered with respiratory, cardiovascular and gastrointestinal drug classes. 47% of the sample had at least one interaction (13% pharmacodynamic, 21% pharmacokinetic, and 13% combined parmacodynamic and pharmacokinetic), while the existence of interactions seemed to be related more to the number of pharmaceuticals and the number of active ingredients (p<0.0001 both), and to a lesser extent, by the physician’s specialty prescribing the monthly treatment (p = 0.021). 41% of the sample presented clinically significant interactions (moderate and severe). There was no relation between age and interactions (95% CI for difference -3.2 to 4.8 years). The existence of clinically significant interactions appeared to be related to the low economic status (p = 0.012), alcohol consumption (p = 0.049), increased number of preparations as well as the number of active substances (p <0.0001 both). In a multivariate analysis, obtained that the odds of a clinically significant interaction with individual self-reported moderategood economic status were 0.27 (95% CI 0.10 to 0.76) times the odds of a person with COPD who considered themselves poor economic status. Public Health & Health Care Management Faculty of Medicine – University of Crete 4 Conclusion: This study reported a high rate of interactions and clinically significant interactions in COPD patients, leading in further investigation.

Language

Greek

Subject

Drug interactions

Medication

Pharmaceutical treatment

Pharmacology

Αλληλεπιδράσεις φαρμάκων

Φαρμακευτική αγωγή

ΧΑΠ

Issue date

2012-07-24