Post-graduate theses
Current Record: 602 of 1266
|
Identifier |
000419863 |
Title |
Ο ρόλος του αναλόγου του νευροστεροειδούς δεϋδροεπιανδροστερόνη (DHEA) ΒΝΝ27 στη σχιζοφρένεια |
Alternative Title |
The role of the dehydroepiandrosterone (DHEA) derivative ΒΝΝ27 in schizophrenia |
Author
|
Ζούπα, Έλλη
|
Thesis advisor
|
Πιτσίκας, Νικόλαος
|
Reviewer
|
Γραβάνης, Αχιλλέας
Παναγής, Γεώργιος
|
Abstract |
Consistent experimental evidence suggests the
involvement of neurosteroid dehydroepiandrosterone (DHEA) in schizophrenia.
BNN27 is a novel DHEA analogue, which devoid of steroidogenic activity and
its neurotrophic effect has been observed. Its role, however, in
schizophrenia has not yet been established. Thus, the present study was
designed to investigate the ability of BNN27 (3 and 6 mg/kg) to counteract
schizophrenia-like behavioral deficits produced by ketamine in rats.
For this purpose, the spontaneous behavior in the open field task, the novel
object recognition task (NORT) and the social interaction (SI) test were used. The
spontaneous behavior in open field task is an experimental model resembling the
positive symptoms of schizophrenia. NORT assesses recognition memory, a type of
memory impaired in schizophrenics, while SI is an experimental model resembling
the negative symptoms of schizophrenia.
Intraperitoneal (i.p.) administration of BNN27 (3 and 6 mg/kg)
reversed ketamine (10 mg/kg, i.p.)-induced hypermotility in open field.
Also, BNN27 (6 mg/kg) attenuated head weaving and ataxia produced by ketamine.
Moreover, intraperitoneal administration of BNN27 (3 and 6 mg/kg)
reversed ketamine (3 mg/kg, i.p.)-induced performance deficits in the NORT both at
the acquisition and storage of memory.
In addition, BNN27 (6 mg/kg, i.p.) seems to attenuate the social isolation
caused by subchronic administration of ketamine (8 mg/kg, i.p.) in the SI test.
Overall, the results of the present study indicate that
BNN27 attenuated schizophrenia-like deficits in animal models which were induced by dysregulation of the glutamatergic system. The current
findings, also, suggest that further studies should be carried out aiming to
elucidate whether or not BNN27 might constitute a potential candidate for
the treatment of this psychiatric disorder.
|
Language |
Greek, English |
Subject |
Ketamine |
|
RAT |
|
Επιμύς |
|
Κεταμίνη |
Issue date |
2018-12-05 |
Collection
|
School/Department--School of Medicine--Department of Medicine--Post-graduate theses
|
|
Type of Work--Post-graduate theses
|
Permanent Link |
https://elocus.lib.uoc.gr//dlib/1/a/c/metadata-dlib-1544783663-469150-3968.tkl
|
Views |
252 |