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Identifier

uch.med.phd//2000psillakis

Title

Προσδιορισμός καρβαμαζεπίνης, φαινυτοϊνης και βαλπροϊκού οξέος στις τρίχες ασθενών σε συστηματική θεραπεία με τα φάρμακα

Creator

Psillakis, Athanasios K

Abstract

Carbamazepine (CBZ), Phenytoin (PHT) and Valproic Acid (VPA) levels were determined in sections of head hair of a hundred forty subjects (seventy one males και sixty nine females), aged from two to eighty seven years old, who were regularly receiving the drugs. Hair sectional analysis included dissolution, liquid phase extraction procedures and high-pressure liquid chromatography (HPLC) or immunoassay (Abbott TDx) analytical techniques. The CBZ mean values in the hair sections, from the 1st section (closest to the hair root) to the 5th section, by HPLC technique, were 26.82, 19.18, 17.28, 15.09, 14.62 μg/g and 21.97, 17.30, 15.03, 13.02, 11.21 μg/g, for female and male subjects, respectively. The corresponding PHT mean values, for female and male subjects, were 18.95, 15.24, 13.08, 11.57, 10.69 μg/g and 17.87, 15.01, 12.45, 12.07, 12.29 μg/g. According to immunoassay technique, the CBZ mean values in the hair sections, from the 1st section (closest to the hair root) to the 5th section, were 30.53, 21.90, 19.83, 17.45, 16.99 μg/g and 25.98, 20.52, 17.15, 14.87, 12.31 μg/g, for female and male subjects, respectively. The corresponding PHT or VPA mean values, for female and male subjects, were 17.88, 15.21, 13.08, 11.89, 10.93 μg/g and 17.78, 14.90, 12.22, 11.91, 12.08 μg/g or 7.08, 8.35, 9.41, 9.65, 9.76 μg/g and 5.69, 6.68, 7.26, 7.84, 8.81 μg/g. The CBZ and PHT hair mean values were showed highest from the similar VPA values, by comparable dosage. Reductions of CBZ and PHT concentrations in hair from the first to the subsequent segments were observed. The corresponding VPA values were increased or decreased slightly. Higher amounts of PHT or VPA were deposited in brown and black, than in blond and gray color type of hairs. There was not clear correlation by the color type of hairs for the CBZ hair values. Also, the drug concentrations in the hair sections were found to be dependent of the drug dosages and the subject ages. Was not found out any relation among the drugs hair levels and the gender or the duration of treatment by the studied drugs. Such, there was not relation for drug means values between the hairs and the blood. Generally, our data indicate the possible use of hair sectional analysis as a marker of the dosage history and of the compliance of patients under long-term treatment with the studied drugs.

Issue date

2000-07-01

Date available

2000-09-26

Collection

School/Department--School of Medicine--Department of Medicine--Doctoral theses

Type of Work--Doctoral theses

Permanent Link

https://elocus.lib.uoc.gr//dlib/7/2/e/metadata-dlib-2000psillakis.tkl

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