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Identifier

000031716

Title

Μορφομετρική μελέτη του μυοκαρδίου σε περιπτώσεις αιφνίδιων θανάτων, συνέπεια πρόσφατου εμφράγματος

Creator

Lazaros, George A

Abstract

Sudden cardiac death due to underlying acute myocardial infarction is one of the leading causes of death. However, in a significant percentage of individuals who died suddenly, no indication of myocardial infarction is found during post-mortem examination, especially when the time interval between symptoms appearance and death is short. In the present study, in 20 individuals who died of myocardial infarction, due to a documented acute coronary thrombosis, within one hour from symptoms onset, we have evaluated certain nuclear morphometric parameters, such as, minimum, maximum, mean and standard deviation perimeter and area. Furthermore, the above parameters were compared with those of a control population in which 20 individuals whose sudden death was caused traffic accidents were included. Statistical elaboration of the results by means of t-test, Mann-Whitney) and analysis of covariance showed a statistically significant difference for all variables except for the minimum area. With stepwise discriminant analysis method, a unique variable was selected, the mean perimeter, which achieved a correct reclassification percentage using Fisher's linear discriminant function of 92.5% (85% and 100% for cases and controls respectively). Moreover, using as a cut-off point for the above parameter 172μ, we could clearly identify the individuals who died suddenly of acute myocardial infarction, as those exceeding that limit (p<0.001, sensitivity 85%, specificity 100%). Our results indicate that nuclear morphometry of the myocardial cells seems to be a reliable diagnostic tool for the diagnosis of recent myocardial infarction in cases of sudden death, even when several of the current available techniques fail to do so. Moreover, the detection of contraction bands in these individuals further supports the above diagnosis.i

Language

Greek

Issue date

1998-07-01

Date available

1998-10-30

Collection

School/Department--School of Medicine--Department of Medicine--Doctoral theses

Type of Work--Doctoral theses

Permanent Link

https://elocus.lib.uoc.gr//dlib/e/6/3/metadata-dlib-1998lazaros.tkl