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Title |
Photodegradable hydrogels for drug delivery applications |
Author
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Χατζάκη, Ιωάννα
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Thesis advisor
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Βαμβακάκη, Μαρία
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Abstract |
Hydrogels are widely used in a variety of biomedical applications, including drug
delivery, matrices for the controlled release of biomolecules and scaffolds for
regenerative medicine. The aim of the present thesis, is the development of
photodegradable hydrogels composed of linear, poly(ethylene glycol) (PEG) chains
with different molecular weights (1000 gr/mol, 1500 gr/mol and 4000 gr/mol), and a
small, difunctional aromatic comonomer as the crosslinker. Dithiol end-functionalized
PEGs with different molecular weights were synthesized in order to be used as the
macromonomer. The resulting products were characterized by proton nuclear
magnetic resonance (1
H NMR) spectroscopy. Hydrogels were prepared at a 1:1 and
2:1 molar ratio of the two components. The prepared thioacetal-based hydrogels were
characterized in terms of their swelling degrees and their ability to encapsulate
hydrophilic and hydrophobic dye molecules. Moreover, the release profile of a
hydrophilic and a hydrophobic dye from the hydrogel in aqueous environments, with
and without irradiation at 254 nm, was studied. The porous structure of the prepared
hydrogels was characterized by scanning electron microscopy (SEM) which showed
that the hydrogels prepared using the 4000 gr/mol PEG dithiol appeared to be highly
porous with larger pores compared to the hydrogels prepared using 1000 gr/mol and
1500 gr/mol PEG dithiol. Finally, in order to verify the photodegradation mechanism
of the hydrogels, the properties of the thioacetal-based hydrogels were studied during
irradiation with UV light at 254 nm.
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Language |
Greek |
Issue date |
2021-11-26 |
Collection
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School/Department--School of Sciences and Engineering--Department of Materials Science and Technology--Graduate theses
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Type of Work--Graduate theses
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Permanent Link |
https://elocus.lib.uoc.gr//dlib/7/6/e/metadata-dlib-1642066870-420876-32078.tkl
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Views |
396 |