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Identifier |
000338976 |
Title |
DNA/αιμία από HSV, CMV, EBV και HHV8 σε HIV-1 ενήλικες. Συσχέτισή της με την ανταπόκριση στη HAART |
Alternative Title |
Research of the effect of herpetic DNA/AEMIA from HSV1 and 2 CMV, EBV and HHV8 on the response to HAART in HIV-1 patients who initiate antiretroviral therapy |
Author
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Παναγιωτάκης, Συμεών
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Thesis advisor
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Σπαντίδος, Δημήτριος
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Reviewer
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Τσατσάκης, Αριστείδης
Τσατσάνης, Χρήστος
Σαμώνης, Γεώργιος
Κραμποβίτης
Ζαφειρόπουλος, Α.
Σουρβίνος, Γεώργιος
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Abstract |
The purpose of this study was to assess the qualitative single and multiple herpes virus DNAemia in the Peripheral Blood Leukocytes (PBLs) of HIV-1-positive patients and its impact on the response to highly active antiretroviral therapy (HAART) and immune reconstitution. All (163) HIV-1-positive patients attending “Syngros AIDS Referral Center” from November 2000 - February 2001 were recruited. CMV, HSV-1, HSV-2, EBV and HHV-8 DNA was detected in PBLs by Polymerase Chain Reaction technique (PCR). Patients’ follow-up comprised regular measurements of CD4+ T-cell count and HIV-1 viral load (VL) for an average period of 21 months. Immune reconstitution was defined as an increase in the CD4 T cell count by above 200 cells/μl, while response to HAART was defined as a decrease in HIV-1 VL to undetectable levels. Single and multiple herpetic DNAemia in PBLs was found to be significantly higher in HIV-1-positive patients compared to healthy controls (P<0.02) for all the viruses detected apart from HSV-2, which was not detected in the PBLs of either population. Concurrent CMV and EBV DNAemia significantly correlates with a delay in the response to HAART (P=0.033) in treatment-naïve patients. Untreated patients with CD4+ T-cell count<200 cells/μl, and with CMV DNAemia, presented a delayed increase in CD4 count after HAART initiation (P=0.035), while multiple herpetic DNAemia in the above patients was borderline associated with immune reconstitution (P=0.068). Conclusively CMV and EBV DNAemia may be a poor prognostic factor for the response to HAART in treatment naïve HIV-1 patients.
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Language |
Greek |
Subject |
Virology |
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Ιολογία |
Issue date |
2007-03-08 |
Collection
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School/Department--School of Medicine--Department of Medicine--Doctoral theses
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Type of Work--Doctoral theses
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Permanent Link |
https://elocus.lib.uoc.gr//dlib/0/1/8/metadata-dlib-2007panagiotakis_sym.tkl
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Views |
302 |