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Identifier |
000382269 |
Title |
Study of microRNA-mRNA interactions related with cancer |
Alternative Title |
Μελέτη microRNA-mRNA αλληλεπιδράσεων σχετιζομένων με καρκίνο |
Author
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Καραθανάσης, Νέστορας
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Thesis advisor
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Ποϊράζη, Παναγιώτα
Καλαντίδης, Κρίτων
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Abstract |
MicroRNAs belong to the large family of small non coding RNAs. They regulate
protein synthesis by binding to their mRNA targets causing mRNA degradation
or translational repression. A large number of miRNAs have been associated with
cancer because they are often found to be located within cancer associated
genomic region (CAGRs/FRA) to target cancer-related genes, and to be
differentially expressed in tumor compared to normal tissues. Previous work in
the Computational Biology lab had identified four new putative miRNA genes
that were located within CAGR. However their mature molecules and their
association with cancer phenotypes were unknown. My thesis focuses on
resolving these two issues, using a combination of theoretical and experimental
techniques. The specific aims of this work are:
-The development of a mature miRNA prediction algorithm(Chapter II, III)
-The identification of the mature miRNA molecules of the newly identified
miRNA genes via a combination of computational and experimental
methods (Chapter IV)
-The utilization of a target prediction algorithm to predict and
experimentally verify interactions between the mature molecules and
cancer-related genes Chapter IV).
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Language |
English |
Subject |
Machine learning |
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miRNA |
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miRNA duplex |
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Αγγελιοφόρο RNA |
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Μηχανική μάθηση |
Issue date |
2014-01-29 |
Collection
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School/Department--School of Sciences and Engineering--Department of Biology--Doctoral theses
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Type of Work--Doctoral theses
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Permanent Link |
https://elocus.lib.uoc.gr//dlib/f/3/7/metadata-dlib-1390903661-530609-20810.tkl
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Views |
291 |