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Identifier |
000433840 |
Title |
Intrinsic computations of a wide range of Boolean functions in apical dendritic branches of a two-layer abstract human pyramidal neuron model |
Author
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Παπαδόπουλος, Σωτήριος
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Thesis advisor
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Ποϊράζη, Παναγιώτα
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Abstract |
Pyramidal neurons form the substrate of elaborate, high-order cognitive functions of humans.
Thus, our ability to understand how these neurons operate is crucial for deciphering brain functions, but
it is constrained by technological barriers, especially in the microscale level. The use of modeling
approaches has been proven very useful in studying neuronal mechanisms and elucidating the key
parameters that govern them, when our experiments fail to do so. In this study, I have modeled a
pyramidal neuron dendrite, as well as its soma, under the assumption that they their inputs can be
described by binary values. The inputs are weighted and integrated resulting in binary outputs, enabling
me to describe the input-output function of the dendrite or the neuron in terms of Boolean Algebra and
truth tables. I have investigated how the computational capacity of a single dendrite -and hence the
neuron- is affected by the characteristics of the dendritic input-output function. I show that a nonmonotone
function provides access to the whole range of computations that can be assigned to a given
number of inputs. Moreover, I reveal that the these computations are state-dependent. This analysis,
therefore, provides insights into how human pyramidal neurons may be able to perform complicated
calculations like non-linearly separable classification
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Language |
English |
Subject |
Abstract neuron models |
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Anti-coincidence detection |
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Boolean Algebra |
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Dendrites |
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Dendritic calcium-mediated action potential (dCaAP) |
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Dendritic computations |
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Dendritic spikes |
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Non-monotone activation function |
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Pyramidal neuron |
Issue date |
2020-12-17 |
Collection
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School/Department--School of Medicine--Department of Medicine--Post-graduate theses
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Type of Work--Post-graduate theses
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Permanent Link |
https://elocus.lib.uoc.gr//dlib/7/8/b/metadata-dlib-1605870171-535835-16646.tkl
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Views |
245 |