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Identifier |
000391237 |
Title |
Μελέτη των επιπέδων έκθεσης σε ενδοκρινικούς διαταράκτες της πληθυσμιακής ομάδας (κοόρτης) μητέρας-παιδιού "ΡΕΑ" (Κρήτη) |
Alternative Title |
Evaluation of exposure to endocrine disruptors among mother-child pairs in Greece (RHEA COHORT) |
Author
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Μυριδάκης, Αντώνης Ιω
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Thesis advisor
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Στεφάνου, Ευριπίδης
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Reviewer
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Βασιλικογιαννάκης, Γεώργιος
Θερμού, Κυριακή
Ορφανόπουλος, Μιχαήλ
Περγαντής, Σπυρίδων
Σπύρος, Απόστολος
Χανιωτάκης, Νικόλαος
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Abstract |
Phthalate esters (PEs), bisphenol-A (BPA) and parabens (PBs) are used widely in everyday
products. They have endocrine disrupting properties and are linked with adverse health effects. Humans
exposed to these chemicals, metabolize and excrete them mostly via urine. Urinary metabolite concentrations
are used as biomarkers of exposure.
A liquid chromatography–tandem mass spectrometry (LC-MS/MS) method was developed in order
to determine eight PEs metabolites, six PBs and BPA in human urine. For the first time: I) all three categories
of the above endocrine disruptors were simultaneously extracted from human urine and II) the separation of
two pairs of structural isomers, namely, iso-/n- butyl paraben and propyl paraben was achieved with a
conventional reversed phase LC column.
The developed method was applied to samples from two hundred and thirty nine (239) pregnant
women, their 2.5-year old children (239), and five hundred (500) 4-year old children, all subjects of the “Rhea”
cohort (Crete). Concentration levels of BPA and PEs metabolites were comparable with other studies
worldwide. PBs levels were higher compared to a relevant study conducted in Denmark. We observed for all
examined compounds, except for di-2-ethylhexyl phthalate (DEHP) and BPA, higher median daily intake (DIu)
for mothers than for their children. DIu for 4-year children was lowest compared to the corresponding for 2.5-
year old children. Low correlations (two-tailed spearman; CC 0.1-0.2; p< 0.01) were observed for di-ethyl
phthalate (DEP), di-n-butyl phthalate (DnBP), butyl-benzyl phthalate (BBP) and ethyl paraben (EPB)
concentrations between mothers and their children. Exposure was assigned to two main sources: a) plastics
related to PE-BPA and, b) to personal care-hygiene products related to PB and DEP (di-ethyl phthalate).
DEHP metabolism seems to be related to age and sex. Indoor air and drinking water PEs daily intake
represented a small fraction of the total daily intake.
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Language |
Greek |
Subject |
Bisphenol-A |
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Electrospray ionisation |
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Exposure biomarkers |
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Liquid chromatography |
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Motherchild cohort Rhea |
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Parabens |
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Phthalate esters |
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Preschool-age children |
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Tandem mass spectrometry |
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Βιοδείκτες έκθεσης |
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Δίδυμη φασματομετρία μάζας |
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Δισφαινόλη-Α |
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Ενδοκρινικοί διαταράκτες |
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Ηλεκτροψεκασμός |
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Κοόρτη μητέρας-παιδιού «ΡΕΑ» |
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Παραβένια |
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Υγρή χρωματογραφία |
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Φθαλικοί εστέρες |
Issue date |
2015-03-18 |
Collection
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School/Department--School of Sciences and Engineering--Department of Chemistry--Doctoral theses
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Type of Work--Doctoral theses
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Permanent Link |
https://elocus.lib.uoc.gr//dlib/2/0/f/metadata-dlib-1427439935-599851-31226.tkl
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Views |
609 |