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Identifier |
000447919 |
Title |
Computational modeling of the trisynaptic circuit DG/CA3/CA1 |
Alternative Title |
Υπολογιστική μοντελοποίησητου τρισυναπτικού δικτύου DG/CA3/CA1 |
Author
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Χατζησάββας, Αλέξανδρος
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Thesis advisor
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Ποϊράζη, Παναγιώτα
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Reviewer
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Χαραλαμπόπουλος, Ιωάννης
Βενυχάκη, Μαρία
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Abstract |
The Hippocampus plays a key role in numerous brain processes such as
episodic memory formation and recall, and spatial navigation. Multiple
streams of previously unrelated information converge to the hippocampal
circuits where important mnemonic functions such as pattern separation
and pattern completion take place. Some of the primary hippocampal
areas include the DG, CA3, and CA1, which comprise the so-called
trisynaptic pathway, a closed processing loop with bidirectional
connections with higher cortical areas. Computational modeling has
been extensively utilized to understand how hippocampal network
dynamics are linked to behavior since such studies often require
experiments that are restricted by technical limitations. However, most
currently available Hippocampus models are often overly simplistic,
ignoring key neuronal and network properties. Importantly, they overlook
the implications of active dendritic mechanisms to network-level
functions. For this reason, we developed a simplified yet biologically
plausible network model of the trisynaptic pathway, which was
extensively validated against experimental data. Our network model
accurately reproduces many essential cellular and network functions,
along with their contribution to pattern separation and pattern
completion. To our knowledge, this is the first hippocampal model of the
complete trisynaptic pathway that also incorporates active dendritic
properties and highly sophisticated connectivity. Hence, our model offers
a flexible experimentation platform for exploring how single-cell
properties, such as dendritic computations and plasticity, or neuronal
network properties like inhibition and network connectivity affect
hippocampal dynamics and well-known memory processes.
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Language |
English |
Subject |
Dendrites |
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Dendritic spikes |
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Dentate Gyrus |
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Hippocampus |
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Interneurons |
Issue date |
2022-03-30 |
Collection
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School/Department--School of Medicine--Department of Medicine--Post-graduate theses
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Type of Work--Post-graduate theses
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Permanent Link |
https://elocus.lib.uoc.gr//dlib/3/8/9/metadata-dlib-1652092109-682092-4761.tkl
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Views |
284 |