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|
Identifier |
000363040 |
Title |
Η επίπτωση του μεταβολικού συνδρόμου σε ασθενείς με ρευματοειδή αρθρίτιδα και ο ρόλος του TNFa. Κλινική και εργαστηριακή μελέτη |
Alternative Title |
The prevalence of metabolic syndrome in patients with rheumatoid arthritis and the role of TNF-a. Clinical and laboratory study |
Author
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Καρβουνάρης, Στυλιανός Α
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Thesis advisor
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Γανωτάκης, Εμμανουήλ
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Reviewer
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Μπούμπας, Δημήτριος
Τσατσάνης, Χρήστος
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Abstract |
Patients with rheumatoid arthritis have an increased risk for cardiovascular disease
(CVD). The prevalence of metabolic syndrome (MetS)—a major contributor to CVD—
in a cohort of patients with rheumatoid arthritis and its relationship with rheumatoid
arthritis related factors is investigated here.
200 outpatients with rheumatoid arthritis (147 women and 53 men), with a mean
(standard deviation (SD)) age of 63 (11) years, and 400 age and sex-matched controls
were studied. MetS was assessed according to the adult treatment panel III criteria and
rheumatoid arthritis disease activity by the disease activity score of 28 joints (DAS28).
A standard clinical evaluation was carried out, and a health and lifestyle questionnaire
was completed.
The overall prevalence of MetS was 44% in patients with rheumatoid arthritis and 41%
in controls (p = 0.5). Patients with rheumatoid arthritis were more likely to have low
high-density lipoprotein cholesterol compared with controls (p = 0.02), whereas
controls were more likely to have increased waist circumference or raised blood
pressure (p = 0.001 and 0.003, respectively). In multivariate logistic regression analysis
adjusting for demographics and rheumatoid arthritis treatment modalities, the risk of
having moderate-to high disease activity (DAS28.3.2) was significantly higher in
patients with MetS compared with those with no MetS components (OR 9.24, 95% CI
1.49 to 57.2, p = 0.016).
A high, albeit comparable to the control population, prevalence of MetS was found in
middle-to older aged patients with rheumatoid arthritis. The correlation of rheumatoid
arthritis disease activity with MetS suggests that the increased prevalence of coronary
heart disease in patients with rheumatoid arthritis may, at least in part, be attributed to
the inflammatory burden of the disease.
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Language |
Greek |
Subject |
Arthritis, Rheumatoid |
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Insulin resistance |
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Metabolic Syndrome |
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TNF-a |
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Αντίσταση στην ινσουλίνη |
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Αρθρίτιδα, Ρευματοειδής |
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Μεταβολικό σύνδρομο |
Issue date |
2009-07-24 |
Collection
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School/Department--School of Medicine--Department of Medicine--Doctoral theses
|
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Type of Work--Doctoral theses
|
Permanent Link |
https://elocus.lib.uoc.gr//dlib/7/7/f/metadata-dlib-5865e3caaa5860614cde1d374e99d496_1294390940.tkl
|
Views |
206 |