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Identifier |
000426018 |
Title |
Απομόνωση και χαρακτηρισμός δευτερογενών μεταβολιτών από το φυτό Hypericum empetrifolium |
Alternative Title |
Isolation and identification of components from the plant Hypericum empetrifolium |
Author
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Σαμιωτάκη, Χρυσούλα Ε.
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Thesis advisor
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Κατερινόπουλος, Χαράλαμπος
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Reviewer
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Περγαντής, Σπύρος
Σπύρος, Απόστολος
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Abstract |
The species Hypericum empetrifolium (Clusiaceae) grows mostly in Turkey and Greece. It is used in traditional medicine by the locals as a therapeutic agent for wound healing, antioxidant and against psoriasis. Our research group opted to examine its ingredients and identify its biologically active components.
Aerial parts of the plant were collected during its blooming period, dried and extracted in a Soxhlet apparatus via the sequential use of increasing polarity: hexane, dichloromethane and methanol. The extracts were subjected to further extractions and column chromatography. Since the methanol extract contains the greater range of components used as therapeutic agents, the methanol extract residue was re-extracted with petroleum ether, ethyl acetate and n-butanol. Analysis of the polar extracts with NMR and ESI-MS techniques led to the identification of a number of phenolic acids, including three “chlorogenic acid” stereoisomers (5-O-caffeoyl-(-)-quinic acid, 3-O-caffeoyl-(+)-quinic acid and 5-O-caffeoyl-epi-quinic acid) and the methyl ester of 3-O-caffeoyl-(+)-quinic acid. A second group of components contained the flavonoids hyperoside, avicularin, guaiaverin, as well as shikimic acid. 5-O-caffeoyl-epi-quinic acid was isolated from the genus Hypericum for the first time, while guaiaverin and methyl ester of 3-O-(+)-caffeoyl-quinic acid were isolated for the first time from the species of Hypericum empetrifolium.
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Language |
Greek |
Subject |
Flavonoids |
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Phenolic acids |
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Secondary metabolites |
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Δευτερογενείς μεταβολίτες |
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Φαινολικά οξέα |
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Φλαβονοειδή |
Issue date |
2019-11-29 |
Collection
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School/Department--School of Sciences and Engineering--Department of Chemistry--Post-graduate theses
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Type of Work--Post-graduate theses
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Permanent Link |
https://elocus.lib.uoc.gr//dlib/9/b/9/metadata-dlib-1574075664-537072-32761.tkl
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Views |
425 |