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|
Identifier |
000449393 |
Title |
Chiral sensing of gases by signal reversing cavity ringdown polarimetry |
Alternative Title |
Ανίχνευση χειρομορφίας αερίων, με χρήση οπτικής κοιλότητας |
Author
|
Ταζές, Κωνσταντίνος Κ.
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Thesis advisor
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Ρακιτζής, Πέτρος
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Abstract |
The subject of this thesis, is the presentation of the development of a commercial grade
polarimeter which promises unparalleled accuracy, compared to the ones available in market.
We present the experimental setup and the results of measurement of chiral optical rotation in
gases.
Chiral rotations emerge from the chiral nature of the molecules that make up the samples we
aim to measure. Being able to accurately determine chiral rotations is of great importance in
multiple scientific fields such as Physics, Chemistry, Pharmacology and Medicine.
In the field of Physics, chiral effects can occur due to the weak-interaction which violates
parity. Moving up, optical activity can emerge due to the chiral structure of most molecules
that consist of more than a few atoms. Thus measuring chiral rotation can help us determine
or verify the values of various fundamental and molecular constants.
In the field of Chemistry and Pharmacology, chiral measurements can help in evaluating
enantiomeric excess in mixes. This is particularly important in Pharmacology, where the
presence of an unwanted enantiomer can render medicines toxic, as in the historic example of
Thalidomide.
In medicine, measuring the concentration of certain chiral substances in samples such as
tears, can help with diagnosing multiple conditions such as dry eye.
Our polarimeter is based on enhancing optical rotation via cavity techniques. It is an
improved form of Cavity Ringdown Polarimetry refined with birefringence and noise
quenching techniques, in the form of counter-propagating beams and signal reversal.
This experimental setup is viable form miniaturization in order to better fit trade standards
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Language |
English |
Subject |
Cavities |
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Chirality |
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Pulses |
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Κοιλότητες |
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Παλμοί |
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Πολωσιμετρία |
Issue date |
2022-07-22 |
Collection
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School/Department--School of Sciences and Engineering--Department of Physics--Post-graduate theses
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Type of Work--Post-graduate theses
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Permanent Link |
https://elocus.lib.uoc.gr//dlib/d/3/6/metadata-dlib-1656662979-777795-30021.tkl
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Views |
460 |