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Identifier

000449393

Title

Chiral sensing of gases by signal reversing cavity ringdown polarimetry

Alternative Title

Ανίχνευση χειρομορφίας αερίων, με χρήση οπτικής κοιλότητας

Author

Ταζές, Κωνσταντίνος Κ.

Thesis advisor

Ρακιτζής, Πέτρος

Abstract

The subject of this thesis, is the presentation of the development of a commercial grade polarimeter which promises unparalleled accuracy, compared to the ones available in market. We present the experimental setup and the results of measurement of chiral optical rotation in gases. Chiral rotations emerge from the chiral nature of the molecules that make up the samples we aim to measure. Being able to accurately determine chiral rotations is of great importance in multiple scientific fields such as Physics, Chemistry, Pharmacology and Medicine. In the field of Physics, chiral effects can occur due to the weak-interaction which violates parity. Moving up, optical activity can emerge due to the chiral structure of most molecules that consist of more than a few atoms. Thus measuring chiral rotation can help us determine or verify the values of various fundamental and molecular constants. In the field of Chemistry and Pharmacology, chiral measurements can help in evaluating enantiomeric excess in mixes. This is particularly important in Pharmacology, where the presence of an unwanted enantiomer can render medicines toxic, as in the historic example of Thalidomide. In medicine, measuring the concentration of certain chiral substances in samples such as tears, can help with diagnosing multiple conditions such as dry eye. Our polarimeter is based on enhancing optical rotation via cavity techniques. It is an improved form of Cavity Ringdown Polarimetry refined with birefringence and noise quenching techniques, in the form of counter-propagating beams and signal reversal. This experimental setup is viable form miniaturization in order to better fit trade standards

Language

English

Subject

Cavities

Chirality

Pulses

Κοιλότητες

Παλμοί

Πολωσιμετρία

Issue date

2022-07-22

Collection