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Identifier

000382269

Title

Study of microRNA-mRNA interactions related with cancer

Alternative Title

Μελέτη microRNA-mRNA αλληλεπιδράσεων σχετιζομένων με καρκίνο

Author

Καραθανάσης, Νέστορας

Thesis advisor

Ποϊράζη, Παναγιώτα
Καλαντίδης, Κρίτων

Abstract

MicroRNAs belong to the large family of small non coding RNAs. They regulate protein synthesis by binding to their mRNA targets causing mRNA degradation or translational repression. A large number of miRNAs have been associated with cancer because they are often found to be located within cancer associated genomic region (CAGRs/FRA) to target cancer-related genes, and to be differentially expressed in tumor compared to normal tissues. Previous work in the Computational Biology lab had identified four new putative miRNA genes that were located within CAGR. However their mature molecules and their association with cancer phenotypes were unknown. My thesis focuses on resolving these two issues, using a combination of theoretical and experimental techniques. The specific aims of this work are: -The development of a mature miRNA prediction algorithm(Chapter II, III) -The identification of the mature miRNA molecules of the newly identified miRNA genes via a combination of computational and experimental methods (Chapter IV) -The utilization of a target prediction algorithm to predict and experimentally verify interactions between the mature molecules and cancer-related genes Chapter IV).

Language

English

Subject

Machine learning

miRNA

miRNA duplex

Αγγελιοφόρο RNA

Μηχανική μάθηση

Issue date

2014-01-29

Collection

School/Department--School of Sciences and Engineering--Department of Biology--Doctoral theses