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Identifier

000380387

Title

Μέτρηση και χειρουργικός έλεγχος της ευχέρειας εκροής σε μοντέλο πειραματόζωου

Alternative Title

Measurement and surgical control of outflow facility in animal model

Author

Λογγάκη, Κωνσταντίνα

Thesis advisor

Δετοράκης, Ευστάθιος

Reviewer

Γκίνης, Χαρίλαος
Παλλήκαρης, Ιωάννης
Τσιλιμπάρης, Μιλτιάδης

Abstract

The glaucoma refers to a set of pathological conditions of the eye which have as common finding the increase of intraocular pressure to such an extent as to cause damage to the optic nerve and limit the visual field. In many cases, patients remain unaware of the problem until severe loss of vision has occurred. In most cases there is no restoration of vision after diagnosis and some patients eventually are blinded. The increase is due to obstruction to outflow of aqueous humor, which is produced and discharged continuously, so if for some reason drainage is blocked, then increased intraocular pressure. There are many pharmaceutical and surgical modalities to reduce intraocular pressure. The purpose of this thesis is to contribute to the development and evaluation of a novel glaucoma valve implanting prototypes in an animal model (rabbits). This valve is designed to increase the rate of aqueous humor outflow and lead to the reduction of intraocular pressure. Initially we measured the intraocular pressure in eight (8) rabbits, placed the antiglaucomatous valve into the left eye of the rabbit and used the right eye as control. Then we followed the intraocular pressure for a period of two months. Additionally to intraocular pressure the outflow facility and ocular rigidity were measured foe each eye. This study, confirmed the increased of outflow facility and the reduction of intraocular pressure at the experimental eye. Moreover, a decrease in the ocular rigidity coefficient (which defines the pressure volume relationship of the eye) was observed.

Language

Greek

Subject

Glaucoma

Ophthalmology

Γλαύκωμα

Issue date

2013-04-16

Collection

School/Department--School of Medicine--Department of Medicine--Post-graduate theses

Type of Work--Post-graduate theses

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