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Identifier |
000451097 |
Title |
Scaffolding techniques and tissue imaging on them |
Alternative Title |
Τεχνικές κατασκευής ικριωμάτων και απεικόνηση ιστού σε αυτά |
Author
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Δασκαλάκης, Παναγιώτης
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Thesis advisor
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Στρατάκης, Εμμανουήλ
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Abstract |
Regenerative medicine and tissue engineering have recently been a trending scientific field in the
world of modern medicine. The future of tissue engineering is highly promising offering solutions for
successful transplantation, repair, regeneration, and self-healing of tissue, organoids, and organs. 3D
printing is a promising technique used as a fabrication methods in creating scaffolds for tissue
engineering. Great advantages using the 3D printing technique are proved to be in creating complex
geometries, gradient porosities, and co-culture of numerous cells, using well-developed biomaterials.
Thus, these applications are limited caused of the low variety in biomaterials and construction
mechanisms that are used yet.
The purpose of this thesis research is the conversion of a standardized 3D printer to an ultra-low-cost
3D-4D bioprinter (constructed from PLA 3D printed parts), and the construction of 3D-4D scaffolds for
cellular responses such as adhesion and proliferation. Cellulose acetate is the chosen bioink for the
bioprinted structure because of the flexible printability of the mixture and the high mechanical
properties, Cellulose Acetate offers. Parametric calculations for the extrusion manipulation are
presented in boards, and firmware commands that had to be changed for temperature safety factors
(fluid and not fused material) are presented as well. 3D scaffolds were designed and developed into
Gcode files for the bioprinter to fabricate, delivering high-quality bioprinted scaffolds after
modification of the printing parameters, bioprinting-mechanism, and bioink composition. The results
showed that the CA scaffolds created from the converted bioprinter offered a better geometrical
structure and resolution compared to other printed scaffolds. Future research is focused on the
development of advanced bioinks, more accurate geometrical modeling, and in-vitro
cytocompatibility studies.
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Language |
English, Greek |
Subject |
Bio-ink |
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Tissue engineering |
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Βιο-εκτύπωση |
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Βιο-μεθάνη |
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Μηχανική ιστών |
Issue date |
2022-07-29 |
Collection
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School/Department--School of Medicine--Department of Medicine--Post-graduate theses
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Type of Work--Post-graduate theses
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Permanent Link |
https://elocus.lib.uoc.gr//dlib/5/8/0/metadata-dlib-1663571551-310133-30690.tkl
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Views |
298 |